基于系统药理学的茵陈作用机制研究(6)
[33] CHEOK CF，VERMA CS，BASELGA J，et al. Translating p53 into the clinic[J]. Nat Rev Clin Oncol，2011，8(1)： 25-37.
[34] ATTALLAH AM，SHIHA GE，ISMAIL H，et al. Expression of p53 protein in liver and sera of patients with liver fibrosis，liver cirrhosis or hepatocellular carcinoma associated with chronic HCV infection[J]. Clin Biochem，2009，42(6)： 455-461.
[35] QIN LX，TANG ZY. The prognosic molecular markers in hepatocellular carcinoma[J]. World J Gastroenterol，2002，8(3)：385-392.
[36] CHENG HW，CHEN YF，WONG JM，et al. Cancer cells increase endothelial cell tube formation and survival by activating the PI3K/Akt signaling pathway[J]. J Exp Clin Cancer Res，2017. DOI： 10.1186/s13046-017-0495-3.
[37] CHEN H，HUANG Y，HUANG J，et al. Gigantol attenuates the proliferation of human liver cancer HepG2 cells through the PI3K/Akt/NF-κB signaling pathway[J]. Oncol Rep，2017，37(2)：865-870.
[38] VARFOLOMEEV E，GONCHAROV T，MAECKER H，et al. Cellular inhibitors of apoptosis are global regulators of NF-kappaB and MAPK activation by members of the TNF family of receptors[J]. Sci Signal，2012. DOI： 10.1126/scisignal.2001878.
[39] 蔡秀紅，黄贻涛，张子平，等. 缺氧诱导因子-1(HIF-1)及其在水生动物中的研究进展[J]. 农业生物技术学报，2014，22(1)：119-132.
[40] 胡韶君，余勤，刘丽珍，等. HIF-1信号通路在介导DMOG动员MSCs中的作用[J].中国比较医学杂志，2015，25(1)： 9-14.
[41] 刘丽愉，杨力芳，曹亚. 低氧诱导因子信号通路的研究新进展[J]. 国际病理科学与临床杂志，2011，31(3)：218- 222.
[42] MARTINEZ-OUTSCHOORN UE，TRIMMER C，LIN Z，et al. Autophagy in cancer associated fibroblasts promotes tumor cell survival： role of hypoxia，HIF1 induction and NF-κB activation in the tumor stromal microenvironment[J]. Cell Cycle，2010，9(17)：3515-3533.
[43] LEGENDRE C，HORI T，LOYER P，et al. Drug-metabolising enzymes are down-regulated by hypoxia in differentiated human hepatoma HepaRG cells： HIF-1α involvement in CYP3A4 repression[J]. Eur J Cancer，2009，45(16)： 2882-2892.
[44] XU H，ZHAO L，FANG Q，et al. MiR-338-3p inhibits hepatocarcinoma cells and sensitizes these cells to sorafenib by targeting hypoxia-induced factor 1alpha[J].PLoS One，2014，9(12)： e115565.
(收稿日期：2017-10-11 修回日期：2018-03-29)
(编辑：张元媛), http://www.100md.com(陈国铭 汤顺莉 邝梓君 黄雁 赵金龙 於菁雯 陈子茵 林洪荣 黄楚瑶 许华)
[34] ATTALLAH AM，SHIHA GE，ISMAIL H，et al. Expression of p53 protein in liver and sera of patients with liver fibrosis，liver cirrhosis or hepatocellular carcinoma associated with chronic HCV infection[J]. Clin Biochem，2009，42(6)： 455-461.
[35] QIN LX，TANG ZY. The prognosic molecular markers in hepatocellular carcinoma[J]. World J Gastroenterol，2002，8(3)：385-392.
[36] CHENG HW，CHEN YF，WONG JM，et al. Cancer cells increase endothelial cell tube formation and survival by activating the PI3K/Akt signaling pathway[J]. J Exp Clin Cancer Res，2017. DOI： 10.1186/s13046-017-0495-3.
[37] CHEN H，HUANG Y，HUANG J，et al. Gigantol attenuates the proliferation of human liver cancer HepG2 cells through the PI3K/Akt/NF-κB signaling pathway[J]. Oncol Rep，2017，37(2)：865-870.
[38] VARFOLOMEEV E，GONCHAROV T，MAECKER H，et al. Cellular inhibitors of apoptosis are global regulators of NF-kappaB and MAPK activation by members of the TNF family of receptors[J]. Sci Signal，2012. DOI： 10.1126/scisignal.2001878.
[39] 蔡秀紅，黄贻涛，张子平，等. 缺氧诱导因子-1(HIF-1)及其在水生动物中的研究进展[J]. 农业生物技术学报，2014，22(1)：119-132.
[40] 胡韶君，余勤，刘丽珍，等. HIF-1信号通路在介导DMOG动员MSCs中的作用[J].中国比较医学杂志，2015，25(1)： 9-14.
[41] 刘丽愉，杨力芳，曹亚. 低氧诱导因子信号通路的研究新进展[J]. 国际病理科学与临床杂志，2011，31(3)：218- 222.
[42] MARTINEZ-OUTSCHOORN UE，TRIMMER C，LIN Z，et al. Autophagy in cancer associated fibroblasts promotes tumor cell survival： role of hypoxia，HIF1 induction and NF-κB activation in the tumor stromal microenvironment[J]. Cell Cycle，2010，9(17)：3515-3533.
[43] LEGENDRE C，HORI T，LOYER P，et al. Drug-metabolising enzymes are down-regulated by hypoxia in differentiated human hepatoma HepaRG cells： HIF-1α involvement in CYP3A4 repression[J]. Eur J Cancer，2009，45(16)： 2882-2892.
[44] XU H，ZHAO L，FANG Q，et al. MiR-338-3p inhibits hepatocarcinoma cells and sensitizes these cells to sorafenib by targeting hypoxia-induced factor 1alpha[J].PLoS One，2014，9(12)： e115565.
(收稿日期：2017-10-11 修回日期：2018-03-29)
(编辑：张元媛), http://www.100md.com(陈国铭 汤顺莉 邝梓君 黄雁 赵金龙 於菁雯 陈子茵 林洪荣 黄楚瑶 许华)